Relationship between Childhood Autism and Gut Microbiota
Keywords:
microbiota, autism, dysbiosis, symbiosis,Abstract
Introduction: Many diseases are related to the gut microbiota due to the role it plays in different physiological processes. The proper functioning of the organism in general depends on the microbiota balance. Its breaking influences the appearance and exacerbation of mental illnesses such as childhood autism.
Objective: Describe the characteristics, composition, functions and importance of the gut
microbiota, as well as the functioning of microbiota-gut-brain axis, and its relationships with mental illnesses such as childhood autism.
Methods: A narrative literature review was carried out through a search in PubMed, Lilacs, Academic Google and Cumed databases. Descriptors were used in English and Spanish.
Analysis and integration of information: Once the literature was reviewed, the main aspects in which the authors agreed regarding the microbiota and its relationship with mental illnesses such as autism were summarized.
Conclusions: An adequate diet once again reinforces the theory of “We are what we eat”; maintaining a balance in eating habits guarantees a balance in the microbiota that helps the proper functioning of the organism. There are multiple functions of microbiota, and within these, its role in metabolism and immunity stands out. It varies throughout life and its imbalance generates an imbalance of neurotransmitters, and thus causes a series of diseases that affect the individual.
Downloads
Download data is not yet available.
References
1. Cani, P D.Human gut microbiome: hopes, threats and promises. [internet] Pubmed, (2018), 67(9): 1716-1725[Consultado el 1 de marzo de 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29934437
2. Bozzi N, Baffoni L, Gaggia F, Di Gioia D. Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Pediatric Diseases. Nutrients. 2018; 10(11). [citado 16 enero 2023] Disponible en: https://doi.org/10.3390/nu10111723
3. Nyangahu, D. and Jaspan, H.Influence of maternal microbiota during pregnancy on infant immunity [internet] Pubmed (2019). [Consultado el 15 Feb 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/31121057
4. Wood J, Alpers D. and Andrews P. Fundamentals of neurogastroenterology. [internet] BMJ journals. (2019) 45:(2) [Consultado el 1 de Marzo de 2023] Disponible en: https://gut.bmj.com/content/45/suppl_2/II6
5. Gómez M, Ramón J, Pérez L. and Blanco J. El eje microbiota-intestino-cerebro y sus grandes proyecciones Revista de Neurología [internet] (2019) 68(3) [Consultado el 2 de Marzo de 2023] Disponible en: https://www.neurologia.com/articulo/2018223
6. Moreno M, Valladares J, Halabe J. Microbioma humano. Rev la Fac Med. 2018;61(6):7–19. [citado 1 Mar 2023] Disponible en: http://www.scielo.org.mx/Scielo.php?scrip=sci_arttext&pid=S002617422018000600007&In g=es.
7. He M, Sun J,Jiang ZQ, Yang YX. Effects of cow's milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study. (internet)Pubmed 2017 25; 16 (1): 72.[Consultado el 4 de Feb de 2023] Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29070042
8. Icaza-Chávez M. Microbiota intestinal en la salud y la enfermedad. Rev. Gastroenterología Mex. 2013;78(4):240-8. [citado 1
Mar 2023] Disponible en: https://doi.org/10.1016/j.rgmx.2013.04.004
9. Gómez C, Salminen S. Chapter 7 Microbiota and the gastro-intestinal system in children. Microbiota in health and disease: from pregnancy to childhood: Wageningen Academic Publishers; 2017. p. 1574-86. Disponible en: https://doi.org/10.3920/978-90-8686-839-1_7
10. Pérez ME, Arrieta MC, Ramer AE, Walter J. A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome. Microbiome. 2017;5(1):48. [citado 1 Mar 2023] Disponible en: https://doi.org/10.1186/s40168-017-0268-4
11. Chong CYL, Bloomfield FH, O'Sullivan JM. Factors Affecting
Gastrointestinal Microbiome Development in Neonates. Nutrients. 2018;10(3). [citado 1 Mar 2023] Disponible en: https://doi.org/10.3390/nu10030274
12. Miller, I. Gut-Brain axis in history and culture. Journal Microbial Ecology in Health and Disease [internet]. Tandfonline.com.(2018), (29):2, [Consultado el 4 de Marzo de 2023]. Disponible en: https://www.tandfonline.com/doi/pdf/10.1080/16512235.2018.1542921
13. Argou I, Zeidán F. Clostridium Bacteria and Autism Spectrum Conditions: A Systematic Review and Hypothetical Contribution of Environmental Glyphosate Levels. Med Sci. 2018;6(2):1–11. [citado 1 Mar 2023] Disponible en: https://doi.org/10.3390/medsci6020029
14. Valles M. The neuroactive potential of the human gut microbiota in quality of life and depression.[internet] PubMed (2019), 4(4):623-632 [Consultado el 2 de Marzo de 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30718848
15. Wan MLY, Ling KH, El-Nezami H, Wang MF. Influence of functional food components on gut health. Rev. Science and nutrition [Internet]. 2019 Ago [citado el14 enero 2023]; 59(12):1927–36. Disponible en: https://search.ebscohost.com.ezproxy.usal.es/login.aspx?direct=true&db=ccm AN=137070 011&site=ehost-live
16. Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R. Functional Genomics of Host- Microbiome Interactions in Humans. Trends Genet. 2018;34(1):30-40. [citado 1 Mar 2023] Disponible en: https://doi.org/10.1016/j.tig.2017.10.001
17. Zaman, S. and Naqvi, I. Role of Personal Growth Initiative as a Moderator between Stress and Mental Health among Adolescents,Pakistan.[internet] Journal of Psychological, (2018) 33(1):12–147. (Consultado el 2 de Feb de 2023) Disponible en: http://search.ebscohost.com.accedys2.bbtk.ull.es/login.aspx?direct=true&db=a9h&AN=131 353896&lang=es&site=ehost-live
18. Ianiro G, Rizzatti G, Plomer M, Lopetuso L, Scaldaferri F, Franceschi F, et al. Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta- Analysis of Randomized Controlled Trials. Nutrients. 2018;10(8). [citado 8 Ene 2023] Disponible en: https://doi.org/10.3390/nu10081074
19. Castañeda C. Microbiota intestinal y salud infantil. Rev Cubana Pediatr. 2018; 90(1):10-9. [citado 4 Feb 2023]Disponible
en: http://scielo.sld.cu/scielo.php?scrip=sci_arttext pid=S003475312018000100010&Ing=es.
20. Whilby M, Ravelo V, Ramos L. Autismo Infantil: Trastornos digestivos asociados. Rev Hosp Psiq de La Habana [Internet]. 2011 [citado 12 Mar 2023]; 8(3):[aprox. 9 p.]. Disponible en: https://wwwrevistahph.sld.cu/hph3-2011/hph01311.htl
21. Carmenate I.D, Salas Y. Perfil sociodemográfico de los trastornos del espectro autista en Sancti Spíritus. Rev. REMIJ 2020;21(1). [citado 12 Mar 2023] Disponible en: https://remij.sld.cu/index.php/remij/article/view/275
22. Karl P, Hatch A, Arcidiacono S, Pearce S, Pantoja I, Doherty L, et al. Effects of psychological, environmental and physical stressors on the gut microbiota. Front Microbiol. 2018;9:1–32. [citado 6 Oct 2023] disponible en: https://doi.org/10.3389/fmicb.2018.02013
23. Feitong Liu, Jie Li, Fan Wu, Huimin Zheng, Qiongling Peng, Hongwei Zhou. Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review. Transl Psychiatry. 2019; 9:43. [citado 31 Oct 2022] Disponible en: https://doi.org/10.1038/s41398-019-0389-6
24. Kang, D.-W.et al. La terapia de transferencia de microbiota altera el ecosistema intestinal y mejora los síntomas gastrointestinales y del autismo: un estudio de etiqueta abierta. [citado 3 Feb 2023]Disponible en: https://doi.org/10.1186/s40168-016-0225-7(2017).
25. Morales S, Colmenares M, Cruz V. Recordemos lo importante que es la lactancia materna. Rev. Fac Med UNAM. 2022; 65(2): 9-25 [citado 23 Mar 2023]Disponible en: https://doi.org/10.22201/fm:24484865e.2022.65.2.02
26. Herrera J. Alimentación funcional para corregir desórdenes gastrointestinales asociados a trastornos del espectro autista: Una revisión sistemática. Nutr. Hosp. [online].2022; 39(3):663-677[citado 23 Mar 2023]disponible en: https://doi.org/10.20960/nh.03898.
27. Santocchi E, Guiducci L, Fulceri F. et al. Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the rol of probiotics on clinical, biochemical and neurophysiological parameters. BMC Psychiatry. 2016; 16 (183) [citado 23 Mar
2023]Disponible en: https://doi.org/10.1186/s12888-016-0887-5
28. Pärtty A, Luoto R, Isolauri E. Effects Of Early Prebiotic and Probiotic Supplementation on Development of Gut Microbiota and Fussing and Crying in Preterm Infants: A Randomized,Double-Blind, Placebo-Controlled Trial. J of Pediatr. 2013; 163(5):1272-1277. [citado 23 Mar 2023]disponible en: https://pubmed.ncbi.nih.gov/23915796/
29. Andreo P, García N, Quesada J, Sánchez EP, Martínez AE. Candida spp. en la microbiota intestinal de las personas con autismo: revisión sistemática. Rev Neurol 2019; 68: 1-6. [citado 23 Mar 2023]disponible en: https://doi.org/10.33588/m.6801.2018129
2. Bozzi N, Baffoni L, Gaggia F, Di Gioia D. Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Pediatric Diseases. Nutrients. 2018; 10(11). [citado 16 enero 2023] Disponible en: https://doi.org/10.3390/nu10111723
3. Nyangahu, D. and Jaspan, H.Influence of maternal microbiota during pregnancy on infant immunity [internet] Pubmed (2019). [Consultado el 15 Feb 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/31121057
4. Wood J, Alpers D. and Andrews P. Fundamentals of neurogastroenterology. [internet] BMJ journals. (2019) 45:(2) [Consultado el 1 de Marzo de 2023] Disponible en: https://gut.bmj.com/content/45/suppl_2/II6
5. Gómez M, Ramón J, Pérez L. and Blanco J. El eje microbiota-intestino-cerebro y sus grandes proyecciones Revista de Neurología [internet] (2019) 68(3) [Consultado el 2 de Marzo de 2023] Disponible en: https://www.neurologia.com/articulo/2018223
6. Moreno M, Valladares J, Halabe J. Microbioma humano. Rev la Fac Med. 2018;61(6):7–19. [citado 1 Mar 2023] Disponible en: http://www.scielo.org.mx/Scielo.php?scrip=sci_arttext&pid=S002617422018000600007&In g=es.
7. He M, Sun J,Jiang ZQ, Yang YX. Effects of cow's milk beta-casein variants on symptoms of milk intolerance in Chinese adults: a multicentre, randomised controlled study. (internet)Pubmed 2017 25; 16 (1): 72.[Consultado el 4 de Feb de 2023] Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29070042
8. Icaza-Chávez M. Microbiota intestinal en la salud y la enfermedad. Rev. Gastroenterología Mex. 2013;78(4):240-8. [citado 1
Mar 2023] Disponible en: https://doi.org/10.1016/j.rgmx.2013.04.004
9. Gómez C, Salminen S. Chapter 7 Microbiota and the gastro-intestinal system in children. Microbiota in health and disease: from pregnancy to childhood: Wageningen Academic Publishers; 2017. p. 1574-86. Disponible en: https://doi.org/10.3920/978-90-8686-839-1_7
10. Pérez ME, Arrieta MC, Ramer AE, Walter J. A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome. Microbiome. 2017;5(1):48. [citado 1 Mar 2023] Disponible en: https://doi.org/10.1186/s40168-017-0268-4
11. Chong CYL, Bloomfield FH, O'Sullivan JM. Factors Affecting
Gastrointestinal Microbiome Development in Neonates. Nutrients. 2018;10(3). [citado 1 Mar 2023] Disponible en: https://doi.org/10.3390/nu10030274
12. Miller, I. Gut-Brain axis in history and culture. Journal Microbial Ecology in Health and Disease [internet]. Tandfonline.com.(2018), (29):2, [Consultado el 4 de Marzo de 2023]. Disponible en: https://www.tandfonline.com/doi/pdf/10.1080/16512235.2018.1542921
13. Argou I, Zeidán F. Clostridium Bacteria and Autism Spectrum Conditions: A Systematic Review and Hypothetical Contribution of Environmental Glyphosate Levels. Med Sci. 2018;6(2):1–11. [citado 1 Mar 2023] Disponible en: https://doi.org/10.3390/medsci6020029
14. Valles M. The neuroactive potential of the human gut microbiota in quality of life and depression.[internet] PubMed (2019), 4(4):623-632 [Consultado el 2 de Marzo de 2023]. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30718848
15. Wan MLY, Ling KH, El-Nezami H, Wang MF. Influence of functional food components on gut health. Rev. Science and nutrition [Internet]. 2019 Ago [citado el14 enero 2023]; 59(12):1927–36. Disponible en: https://search.ebscohost.com.ezproxy.usal.es/login.aspx?direct=true&db=ccm AN=137070 011&site=ehost-live
16. Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R. Functional Genomics of Host- Microbiome Interactions in Humans. Trends Genet. 2018;34(1):30-40. [citado 1 Mar 2023] Disponible en: https://doi.org/10.1016/j.tig.2017.10.001
17. Zaman, S. and Naqvi, I. Role of Personal Growth Initiative as a Moderator between Stress and Mental Health among Adolescents,Pakistan.[internet] Journal of Psychological, (2018) 33(1):12–147. (Consultado el 2 de Feb de 2023) Disponible en: http://search.ebscohost.com.accedys2.bbtk.ull.es/login.aspx?direct=true&db=a9h&AN=131 353896&lang=es&site=ehost-live
18. Ianiro G, Rizzatti G, Plomer M, Lopetuso L, Scaldaferri F, Franceschi F, et al. Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta- Analysis of Randomized Controlled Trials. Nutrients. 2018;10(8). [citado 8 Ene 2023] Disponible en: https://doi.org/10.3390/nu10081074
19. Castañeda C. Microbiota intestinal y salud infantil. Rev Cubana Pediatr. 2018; 90(1):10-9. [citado 4 Feb 2023]Disponible
en: http://scielo.sld.cu/scielo.php?scrip=sci_arttext pid=S003475312018000100010&Ing=es.
20. Whilby M, Ravelo V, Ramos L. Autismo Infantil: Trastornos digestivos asociados. Rev Hosp Psiq de La Habana [Internet]. 2011 [citado 12 Mar 2023]; 8(3):[aprox. 9 p.]. Disponible en: https://wwwrevistahph.sld.cu/hph3-2011/hph01311.htl
21. Carmenate I.D, Salas Y. Perfil sociodemográfico de los trastornos del espectro autista en Sancti Spíritus. Rev. REMIJ 2020;21(1). [citado 12 Mar 2023] Disponible en: https://remij.sld.cu/index.php/remij/article/view/275
22. Karl P, Hatch A, Arcidiacono S, Pearce S, Pantoja I, Doherty L, et al. Effects of psychological, environmental and physical stressors on the gut microbiota. Front Microbiol. 2018;9:1–32. [citado 6 Oct 2023] disponible en: https://doi.org/10.3389/fmicb.2018.02013
23. Feitong Liu, Jie Li, Fan Wu, Huimin Zheng, Qiongling Peng, Hongwei Zhou. Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review. Transl Psychiatry. 2019; 9:43. [citado 31 Oct 2022] Disponible en: https://doi.org/10.1038/s41398-019-0389-6
24. Kang, D.-W.et al. La terapia de transferencia de microbiota altera el ecosistema intestinal y mejora los síntomas gastrointestinales y del autismo: un estudio de etiqueta abierta. [citado 3 Feb 2023]Disponible en: https://doi.org/10.1186/s40168-016-0225-7(2017).
25. Morales S, Colmenares M, Cruz V. Recordemos lo importante que es la lactancia materna. Rev. Fac Med UNAM. 2022; 65(2): 9-25 [citado 23 Mar 2023]Disponible en: https://doi.org/10.22201/fm:24484865e.2022.65.2.02
26. Herrera J. Alimentación funcional para corregir desórdenes gastrointestinales asociados a trastornos del espectro autista: Una revisión sistemática. Nutr. Hosp. [online].2022; 39(3):663-677[citado 23 Mar 2023]disponible en: https://doi.org/10.20960/nh.03898.
27. Santocchi E, Guiducci L, Fulceri F. et al. Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the rol of probiotics on clinical, biochemical and neurophysiological parameters. BMC Psychiatry. 2016; 16 (183) [citado 23 Mar
2023]Disponible en: https://doi.org/10.1186/s12888-016-0887-5
28. Pärtty A, Luoto R, Isolauri E. Effects Of Early Prebiotic and Probiotic Supplementation on Development of Gut Microbiota and Fussing and Crying in Preterm Infants: A Randomized,Double-Blind, Placebo-Controlled Trial. J of Pediatr. 2013; 163(5):1272-1277. [citado 23 Mar 2023]disponible en: https://pubmed.ncbi.nih.gov/23915796/
29. Andreo P, García N, Quesada J, Sánchez EP, Martínez AE. Candida spp. en la microbiota intestinal de las personas con autismo: revisión sistemática. Rev Neurol 2019; 68: 1-6. [citado 23 Mar 2023]disponible en: https://doi.org/10.33588/m.6801.2018129
Downloads
Published
2023-04-28
How to Cite
1.
Carmenate Rodriguez ID, Alvarez Borges CR, Clemente Molina M. Relationship between Childhood Autism and Gut Microbiota. Rev. Hosp. Psiq. Habana [Internet]. 2023 Apr. 28 [cited 2025 Sep. 13];20(1):e309. Available from: https://revhph.sld.cu/index.php/hph/article/view/309
Issue
Section
Artículo de revisión
